Schizophrenia Essay Example | Topics and Well Written Essays - 1250 words

Schizophrenia - Essay Example This difference in levels of cognition in various patients led to more research into other underlying pathologic pathways responsible for severe cognitive impairment in NPI patients but was apparently working fine in patients on NPNN category. Brain morphometry was used to analyze differences. Both groups were tested against each other on the basis of four tests to asses the attention and working memory (verbal and nonverbal) and were confirmed by California verbal learning test and degraded stimulus continuous performance test. The standard deviation within 0.5 was the cut off for near normal cognition whereas 1 standard deviation below normal rendered the patient cognitively impaired. They gray matter was found to be smaller in both the groups along with larger third ventricle. An additional pathology found in NPI was that along with the gray matter, their white matter was also decreased in volume. The lateral ventricle cavity was also enlarged. Whitford et al (2007) further invest igated the white matter abnormalities in schizophrenics and also studied whether the degenerative changes are progressive. T1 weighted magnetic resonance images (MRI) of 41 first- episode schizophrenics were compared against those of 47 normal comparable people for baseline volume of white matter using voxel-based morphometry in statistical parametric mapping- 2 (SPM2). The schizophrenics had decreased volume of white matter in frontal and temporal lobes. However there was an increase in white matter at frontoparietal junctions on both sides. The longitudinal changes at follow up after 2 to 3 years were compared using tensor based morphometry which showed decreased white matter bilaterally in middle and inferior temporal cortices of schizophrenics. The neural connection abnormalities were attributed to this progressive loss of white matter. The structural brain abnormalities at the time of first psychotic episode were studied by Fannon et al (2000) whose research involved 37 patient s going through their first episode of psychosis. T1 weighted steady brain scans of 1.5 mm contiguous sections were obtained and volumetric brain measurements were taken. The patients were found to have structural deviations and there was generalized reduction in brain volume, along with enlarged third and lateral ventricles. Cortical and temporal gray matter was found to be decreased. Schizophrenia is a chronic progressive mental disorder. It is associated with cognitive impairment and worsening interpersonal skills. The attacks are accompanied by hallucinations and delusions. Person feels that he is hearing different sorts of voices and has false beliefs and perceptions. There is extreme emotional instability and the patient may suffer from depression or social isolation. Cognitive decline involves memory impairment, decreased ability to pay attention and difficulty in functional execution of activities. The abnormalities are attributed to abnormal distribution and ratios of gray and white matter in the brain. Apart from that, increase in size of ventricular cavities as well as generalized reduction in brain volume also adds to affect the typical schizophrenic picture. The result is alterations in various brain functions owing to